AsthmaNet Studies for Children

SIENA

Steroids In Eosinophil Negative Asthma

Most people with asthma have inflammation in their airway. Asthma controller medications, like inhaled corticosteroids, are meant to reduce inflammation in the airway. Reducing airway inflammation should make one's breathing easier. However, many people with asthma don't breathe easier when they take an inhaled corticosteroid.

We know that there are several types of cells that can cause airway inflammation. However, inhaled corticosteroids mostly target only one cell called the eosinophil. The purpose of this study is to find out if people should take an asthma controller medication based on the type of inflammatory cells present in their airway. More details may be found on the clinicaltrials.gov website by clicking here.

SIENA is currently enrolling participants ages 12 and older in the following areas:

Atlanta, GA
Boston, MA
Chicago, IL
Cleveland, OH
Denver, CO
Durham, NC
Jacksonville, FL
Madison, WI
New York, NY
Oakland, CA
Orlando, FL
Pittsburgh, PA
Raleigh, NC
St. Louis, MO
San Francisco, CA
Tucson, AZ
Winston-Salem, NC

STICS

Enrollment Complete

Step-up Yellow Zone Inhaled Corticosteroids to Prevent Exacerbations

Most people with asthma use an action plan to guide their asthma treatment. Written asthma action plans are usually color-coded. "Green" means that asthma symptoms are well controlled. "Yellow" means that asthma symptoms are not well controlled and asthma treatment may need to change. "Red" means a severe worsening of symptoms. Red zone treatment is usually an oral corticosteroid, like prednisone.

The purpose of this study is to find the best yellow zone action plan strategy for children with asthma based on the child's asthma symptoms. Finding the best yellow zone strategy may prevent children from entering the red zone and having to take prednisone. The study is also trying to determine which yellow zone strategy leads to the least total corticosteroid (oral and inhaled) use for children with asthma.

The STICS study is currently recruiting children ages 5-11 who have had at least one bad asthma attack in the past year and are receiving low-dose inhaled corticosteroids. More details may be found on the clinicaltrials.gov website by clicking here.

The following locations are participating in this study:

Albuquerque, NM
Atlanta, GA
Boston, MA
Chicago, IL
Cleveland, OH
Denver, CO
Jacksonville, FL
Madison, WI
Oakland, CA
Orlando, FL
Pittsburgh, PA
St. Louis, MO
San Francisco, CA
Tucson, AZ
Winston-Salem, NC

BARD

Enrollment Complete

Best African American Response to Asthma Drugs

The purpose of this study is to find the best treatment to add for African American/Black people who have asthma that is not well controlled on a low dose of inhaled steroid. The BARD study will also try to find out if African American/Black adults and children differ in how they respond to the medications used in this study. This study is currently recruiting children, teens and adults ages 5 and older who have at least one African American/Black grandparent. More details may be found on the clinicaltrials.gov website by clicking here.

Study sites are located in the following areas; please note that not all sites accept both child and adult participants. Please contact the site for details by clicking on the city below:

Albuquerque, NM
Atlanta, GA
Boston, MA
Chicago, IL
Cleveland, OH
Denver, CO
Durham, NC
Jacksonville, FL
Madison, WI
Milwaukee, WI
New York, NY
Oakland, CA
Orlando, FL
Pittsburgh, PA
Raleigh, NC
St. Louis, MO
San Francisco, CA
Tucson, AZ
Winston-Salem, NC

INFANT-AVICA

Study Complete

INdividualized therapy For Asthma iN Toddlers (INFANT), and Acetaminophen Vs. Ibuprofen in Children with Asthma (AVICA)

INFANT and AVICA are two separate but combined studies.

INFANT is designed to determine whether one asthma controller-medication for preschool children with persistent asthma works better than another for these children, and to see if there is something about a child that helps doctors predict which treatment would work better. For example, maybe one treatment works best in boys who also have allergies. More information about the INFANT study may be found on the clinicaltrials.gov website by clicking here.

AVICA is designed to find out if different fever/pain medicines have an effect on asthma symptoms in preschool children with persistent asthma. More information about the AVICA study may be found on the clinicaltrials.gov website by clicking here.

This combined study enrolled children between 12 and 59 months of age in the following locations:

Atlanta, GA
Boston, MA
Chicago, IL
Cleveland, OH
Denver, CO
Jacksonville, FL
Madison, WI
New York, NY
Oakland, CA
Orlando, FL
Pittsburgh, PA
St. Louis, MO
San Francisco, CA
Tucson, AZ
Winston-Salem, NC

APRIL-OCELOT

Study Complete

Azithromycin for Preventing the development of upper Respiratory track Illness into Lower respiratory track symptoms in children (APRIL), and Oral Corticosticosteroids for treating Episodes of significant LOwer respiratory Tract symptoms in children (OCELOT)

APRIL and OCELOT are two separate but linked studies of pre-school age children with asthma. They are designed to identify new treatment approaches to recurrent, severe episodes of lower respiratory tract symptoms in these young children. More information may be found on the clinicaltrials.gov website by clicking here.

This combined study enrolled children between 12 and 71 months of age in the following locations:

Albuquerque, NM
Atlanta, GA
Boston, MA
Chicago, IL
Cleveland, OH
Denver, CO
Madison, WI
Milwaukee, WI
Oakland, CA
Pittsburgh, PA
Raleigh, NC
St. Louis, MO
San Francisco, CA
Tucson, AZ
Winston-Salem, NC
Asthmanet Studies
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